Category: iodides-buliding-blocksOn November 9, 2016 ,《Pd-Catalyzed γ-C(sp3)-H Arylation of Free Amines Using a Transient Directing Group》 appeared in Journal of the American Chemical Society. The author of the article were Wu, Yongwei; Chen, Yan-Qiao; Liu, Tao; Eastgate, Martin D.; Yu, Jin-Quan. The article conveys some information:
In the presence of Pd(OAc)2 and using AgO2CCF3 and H2O as additives in AcOH/(F3C)2CHOH, 20 mol% 2-hydroxy-3-pyridinecarboxaldehyde forms a transient directing group with primary alkylamines such as cyclohexylamine which directs their regioselective (and in some cases, diastereoselective) arylation reactions with aryl and heteroaryl iodides such as RI followed by Boc protection to yield Boc-protected γ-aryl amines such as I in 43-91% yields (in most cases with high selectivity for the monoarylated products). Importantly, the catalyst and the directing group loading can be lowered to 2% and 4% resp., thus demonstrating high efficiency of this newly designed transient directing group. A tetrahydronaphthyridine II was prepared from 2-methyl-1-butanamine and 2-fluoro-3-iodopyridine by a one-pot directed arylation and cyclization. The experimental process involved the reaction of 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7Category: iodides-buliding-blocks)
2-Chloro-5-iodo-3-(trifluoromethyl)pyridine(cas: 887707-25-7) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com