In 2019,Journal of Organic Chemistry included an article by Wisniewski, Steven R.; Stevens, Jason M.; Yu, Miao; Fraunhoffer, Kenneth J.; Romero, Evan O.; Savage, Scott A.. SDS of cas: 591-18-4. The article was titled 《Utilizing Native Directing Groups: Synthesis of a Selective IKur Inhibitor, BMS-919373, via a Regioselective C-H Arylation》. The information in the text is summarized as follows:
BMS-919373 (I) is a highly functionalized quinazoline under investigation as a selective, potent Ikur current blocker. By utilizing the aminomethylpyridine side chain at C-4, a selective C-H functionalization at C-5 was invented, enabling the efficient synthesis of this mol. The strategy of leveraging this inherent directing group allowed the synthesis of this complex heterocycle in only six steps from commodity chems. The scope of the C-H activation was further investigated, and the generality of the transformation across a series of bicyclic aromatic heterocycles was explored. In the experiment, the researchers used many compounds, for example, 1-Bromo-3-iodobenzene(cas: 591-18-4SDS of cas: 591-18-4)
1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.SDS of cas: 591-18-4 Further, it is involved in the preparation of oxygen-tethered 1,6-enynes.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com