Unnava, Ramanjaneyulu; Chahal, Kapil; Reddy, Kallu Rajender published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Synthesis of substituted 1,2-dihydroisoquinolines via Ni(II) and Cu(I)/Ag(I) catalyzed double nucleophilic addition of arylamines to ortho-alkynyl donor-acceptor cyclopropanes (o-ADACs)》.Synthetic Route of C3H9IOS The article contains the following contents:
A concise approach for the synthesis of substituted 1,2-dihydroisoquinolines via double nucleophilic addition of primary arylamines to ortho-alkynyl donor-acceptor cyclopropanes (o-ADACs) in the presence of a catalytic Ni(ClO4)2·6H2O and CuI/AgOTf system has been developed. Further applying this protocol, some of the derived malonates were converted into the corresponding monoesters under Krapcho decarboxylation reaction conditions. Thereafter, these esters were transformed into the resp. acids and alcs. In addition, multifunctionalized 4-(2,2,2-trifluoroacetyl) 1,2-dihydroisoquinolines were also obtained with excess TFAA. The experimental process involved the reaction of Trimethylsulfoxonium iodide(cas: 1774-47-6Synthetic Route of C3H9IOS)
Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Synthetic Route of C3H9IOS
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com