COA of Formula: C6H3ClINO2On October 31, 2007 ,《Applicability aspects of transition metal-catalyzed aromatic amination protocols in medicinal chemistry》 appeared in Advanced Synthesis & Catalysis. The author of the article were Tasler, Stefan; Mies, Jan; Lang, Martin. The article conveys some information:
The application of palladium- and copper-catalyzed reactions for the aromatic amination of pharmacol. relevant scaffolds is investigated. The focus is set on the scope of several protocols for the introduction of amines of broad structural diversity, allowing for the synthesis of numerous derivatives of one biol. hit structure for screening in biol. assay systems. Thus, attaining optimized yields and TONs had not a major priority, most important were practical aspects, that is no further purification and drying of reagents and solvents had to be envisaged, ideally only a few transition metal-based protocols had to be applied for synthesizing structurally diverse compounds in sufficient amounts (several milligrams) for screening without any fine-tuning of conditions and catalytic systems. After reading the article, we found that the author used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3COA of Formula: C6H3ClINO2)
1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides.COA of Formula: C6H3ClINO2 The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com