Tague, Andrew J.; Putsathit, Papanin; Riley, Thomas V.; Keller, Paul A.; Pyne, Stephen G. published their research in ACS Medicinal Chemistry Letters in 2021. The article was titled 《Positional Isomers of Biphenyl Antimicrobial Peptidomimetic Amphiphiles》.Quality Control of 3-Iodophenol The article contains the following contents:
Small-mol. antimicrobial peptidomimetic amphiphiles represent a promising class of novel antimicrobials with the potential for widespread therapeutic application. To investigate the role of spatial positioning for key hydrophobic and hydrophilic groups on the antimicrobial efficacy and selectivity, positional isomers of the lead biphenyl antimicrobial peptidomimetic compound 1 were synthesized and subjected to microbial growth inhibition and mammalian toxicity assays. Positional isomer 4 exhibited 4-8x increased efficacy against the pathogenic Gram-neg. bacteria Pseudomonas aeruginosa and Escherichia coli (MIC = 2 μg/mL), while isomers 2, 3, and 7 exhibited a 4x increase in activity against Acinetobacter baumannii (MIC = 4 μg/mL). Changes in mol. shape had a significant impact on Gram-neg. antibacterial efficacy and the resultant spectrum of activity, whereas all structural isomers exhibited significant efficacy (MIC = 0.25-8 μg/mL) against Gram-pos. bacterial pathogens (e.g., methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis). In the experimental materials used by the author, we found 3-Iodophenol(cas: 626-02-8Quality Control of 3-Iodophenol)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Quality Control of 3-Iodophenol Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com