In 2022,Sen, Anirban; Kumar, Rohit; Pandey, Swechchha; Vipin Raj, K.; Kumar, Pawan; Vanka, Kumar; Chikkali, Samir H. published an article in European Journal of Organic Chemistry. The title of the article was 《Mechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation》.Recommanded Product: 626-02-8 The author mentioned the following in the article:
Although hybrid bidentate ligands are known to yield highly enantioselective products in asym. hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile vs. C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72%). When L1 was treated with [Rh], 31P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92%). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1-2 bar H2 pressure, at room temperature The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson’s disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer. In the part of experimental materials, we found many familiar compounds, such as 3-Iodophenol(cas: 626-02-8Recommanded Product: 626-02-8)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Recommanded Product: 626-02-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com