Salerno, Silvia; Amendola, Giorgio; Angeli, Andrea; Baglini, Emma; Barresi, Elisabetta; Marini, Anna Maria; Ravichandran, Rahul; Viviano, Monica; Castellano, Sabrina; Novellino, Ettore; Da Settimo, Federico; Supuran, Claudiu T.; Cosconati, Sandro; Taliani, Sabrina published an article in 2021. The article was titled 《Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold》, and you may find the article in European Journal of Medicinal Chemistry.Quality Control of 1-Chloro-3-iodobenzene The information in the text is summarized as follows:
Synthesis of a set of new bicyclic tetrahydroindazoles featuring a secondary sulfonamide I [R1 = H, Me, C6H5; R2 = H, Me: R3 = H, 3-Me, 4-Cl, etc.] were described. Biol. evaluation of the inhibitory activity against the hCA I, II, IV, and IX isoforms allowed drawing a structure-activity relationship profile that was rationalized through theor. studies. The new mols. I into the single portions influencing the zinc chelation properties and the selectivity profile thereby which offerred a new platform for the discovery of new isotype selective CA inhibitors. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-3-iodobenzene(cas: 625-99-0Quality Control of 1-Chloro-3-iodobenzene)
1-Chloro-3-iodobenzene(cas: 625-99-0) belongs to organic iodides.Quality Control of 1-Chloro-3-iodobenzene The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com