Sakamoto, Takao; Kondo, Yoshinori; Watanabe, Ryo; Yamanaka, Hiroshi published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Condensed heteroaromatic ring systems. VII. Synthesis of thienopyridines, thienopyrimidines, and furopyridines from o-substituted N-heteroarylacetylenes》.COA of Formula: C6H6ClIN2 The author mentioned the following in the article:
Alkynylation of iodopyrimidines I (R = H, Me, Me2CH, MeS; R1 = H, Me, OMe; R2 = H) with Me3SiCCH gave 70-83% I (R2 = CCSiMe3), which were cyclized with NaSH to give 53-95% 8 thienopyrimidines II. In addition to this study using 4-Chloro-5-iodo-2,6-dimethylpyrimidine, there are many other studies that have used 4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6COA of Formula: C6H6ClIN2) was used in this study.
4-Chloro-5-iodo-2,6-dimethylpyrimidine(cas: 83410-16-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C6H6ClIN2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com