In 2022,Sabourin, Axel; Dufour, Jeremy; Vors, Jean-Pierre; Bernier, David; Montchamp, Jean-Luc published an article in European Journal of Organic Chemistry. The title of the article was 《Synthesis of Carbon- and Nitrogen-Substituted 5- and 6-Membered Benzophostams》.Quality Control of 4-Iodopyridine The author mentioned the following in the article:
Previously, the synthesis of the novel 6-membered and a series of P-substituted 5-membered benzophostams was accomplished. Here, the synthesis of N- and C-substituted benzophostams is presented. For N-substitution, alkylation was accomplished using the heterocycle, LiHMDS and an alkyl halide, or alternatively by copper-catalyzed cyclization of the N-alkyl phosphonamide. N-Arylation could similarly be accomplished on the preformed heterocycle or on the phosphonamide precursor via copper-catalyzed cross-coupling. Dimethylation at the benzylic position could be conducted with LiHMDS and Me iodide. However, due to the significant cost of LiHMDS, a much less expensive and more efficient alternative approach was developed relying on a palladium-catalyzed reductive Heck reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Quality Control of 4-Iodopyridine)
4-Iodopyridine(cas: 15854-87-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Quality Control of 4-Iodopyridine
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com