Computed Properties of C6H3ClINO2On September 30, 2019 ,《Sonogashira coupling reactions: Synthesis of 4-substituted-6-methyl-2-(methylthio)pyrimidines catalyzed by Pd-Cu》 was published in Journal of Chemical Research. The article was written by Rezaeimanesh, Fatemeh; Bakherad, Mohammad; Nasr-Isfahani, Hossein. The article contains the following contents:
An efficient method was developed for the synthesis of 4-(3-arylprop-2-ynyloxy)-6-methyl-2-(methylthio)pyrimidines via palladium-catalyzed Sonogashira reactions of 4-methyl-2-(methylthio)-6-(prop-2-yn-1-yloxy)pyrimidine with electron-poor aryl iodides in acetonitrile at room temperature Excellent yields of the products were obtained in reaction times of 9-11 h. In the part of experimental materials, we found many familiar compounds, such as 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Computed Properties of C6H3ClINO2)
1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Computed Properties of C6H3ClINO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com