Mashiko, Tomoya; Shingai, Yuta; Sakai, Jun; Kamo, Shogo; Adachi, Shinya; Matsuzawa, Akinobu; Sugita, Kazuyuki published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Total Synthesis of Cochlearol B via Intramolecular [2+2] Photocycloaddition》.Safety of 3-Iodophenol The article contains the following contents:
Herein, authors describe the first total synthesis of cochlearol B (I), a meroterpenoid natural product featuring a 4/5/6/6/6-fused pentacyclic structure. Key steps, oxidative cyclization and subsequent intramol. [2+2] photocycloaddition, which constructed the pentacyclic structure in highly stereoselective manner, allowed efficient access to cochlearol B with the longest linear sequence of 16 steps, and in 9% overall yield. Single-crystal X-ray crystallog. anal. clearly confirmed the stereochem. of cochlearol B. The results came from multiple reactions, including the reaction of 3-Iodophenol(cas: 626-02-8Safety of 3-Iodophenol)
3-Iodophenol(cas: 626-02-8) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 3-Iodophenol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com