《Experimental and computational evidence on gold-catalyzed regioselective hydration of phthalimido-protected propargylamines: an entry to β-amino ketones》 was written by Marsicano, Vincenzo; Arcadi, Antonio; Aschi, Massimiliano; Michelet, Veronique. Safety of 1-Bromo-3-iodobenzene And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:
The results of investigations on the Au-catalyzed regioselective hydration reaction of both alkyl- and aryl-substituted N-propargyl phthalimides I (R = CH3, C6H5, 2-thienyl, etc.) directed to the selective formation of the corresponding β-phthalimido ketones II are described. Exptl. data, in particular the observed regioselectivity, have been qual. supported by quantum-chem. calculations carried out on model systems in the framework of D. Functional Theory (DFT) followed by quantum theory of atoms in mols. (QTAIMS). The results suggest that the electronic features of the initial adduct between the propargyl triple bond and the Au(I) catalyst, in particular the character of the gold-triple bond interaction, are essential for the observed regioselectivity. Other effects, such as the presence of the solvent and the formation of a H-bond between the water mol. and the phthalimido moiety, although apparently irrelevant for the regioselectivity, have proven to be kinetically and catalytically rather important.1-Bromo-3-iodobenzene(cas: 591-18-4Safety of 1-Bromo-3-iodobenzene) was used in this study.
1-Bromo-3-iodobenzene(cas: 591-18-4) has been used in the preparation of 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodec-1-ene and 1-(3′-bromophenyl)-3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooct-1-ene.Safety of 1-Bromo-3-iodobenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com