《Ligand-Controlled Direct γ-C-H Arylation of Aldehydes》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Li, Bijin; Lawrence, Brianna; Li, Guigen; Ge, Haibo. Product Details of 624-31-7 The article mentions the following:
The first example of PdII-catalyzed γ-C(sp3)-H functionalization of aliphatic and benzoheteroaryl aldehydes was developed using a transient ligand and an external ligand, concurrently. A wide array of γ-arylated aldehydes were readily accessed without preinstalling internal directing groups. The catalytic mechanism was studied by performing deuterium-labeling experiments, which indicated that the γ-C(sp3)-H bond cleavage is the rate-limiting step during the reaction process. This reaction could be performed on a gram scale, and also demonstrated its potential application in the synthesis of new mechanofluorochromic materials with blue-shifted mechanochromic properties. In the experiment, the researchers used 1-Iodo-4-methylbenzene(cas: 624-31-7Product Details of 624-31-7)
1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Product Details of 624-31-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com