《Palladium-Catalyzed Synthesis of α-Carbonyl-α’-(Hetero)aryl Sulfoxonium Ylides: Scope and Insight into the Mechanism》 was published in Journal of Organic Chemistry in 2020. These research results belong to Janot, Christopher; Chagnoleau, Jean-Baptiste; Halcovitch, Nathan R.; Muir, James; Aissa, Christophe. Recommanded Product: Trimethylsulfoxonium iodide The article mentions the following:
Despite recent advances, a general method for the synthesis of α-carbonyl-α’-(hetero)aryl sulfoxonium ylides is needed to benefit more greatly from the potential safety advantages offered by these compounds over the parent diazo compounds Herein, the palladium-catalyzed cross-coupling of aryl bromides and triflates with α-carbonyl sulfoxonium ylides is reported. The use of this method for the modification of an active pharmaceutical ingredient and to the synthesis of a key precursor of antagonists of the neurokinin-1 receptor is also reported. In addition, the mechanism of the reaction was inferred from several observations. Thus, the oxidative addition complex [(XPhos)PhPdBr] and its dimer were observed by 31P{1H} NMR and these complexes were shown to be catalytically and kinetically competent. Moreover, a complex resulting from the transmetallation of [(XPhos)ArPdBr] (Ar = p-CF3-C6H4) with a model sulfoxonium ylide was observed by mass spectrometry. Finally, the partial rate law suggests that the transmetallation of and the subsequent deprotonation are rate-determining in the catalytic cycle. In addition to this study using Trimethylsulfoxonium iodide, there are many other studies that have used Trimethylsulfoxonium iodide(cas: 1774-47-6Recommanded Product: Trimethylsulfoxonium iodide) was used in this study.
Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.Recommanded Product: Trimethylsulfoxonium iodide
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com