In 2019,Chinese Journal of Structural Chemistry included an article by Hui, Jia; Zhong, Han-Yu; Zhang, Jing-Yi. COA of Formula: C3H9IOS. The article was titled 《Synthesis, crystal structure and bioactivity of ethyl 1 1-((2 2-Bromophenyl)carbamoyl) carbamoyl)-2-(3,4,5 3,4,5- trimethoxyphenyl)cyclopropanecarboxylate》. The information in the text is summarized as follows:
Many small-mol. compounds were reported as microtubule-inhibitor with potential anticancer activities, such as combretastatin-A4 (CA-4) analog. The title compound which is one novel cyclopropylamide analog of CA-4, namely as Et 1-((2-bromophenyl)car- bamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 8.8002 ( 6), b = 11.4525(8), c = 21.7870(16) Å, beta = 93.810(3)°, V = 2190.9(3) Å3, Z = 4, C22H23BrNO6, Mr = 477.32477.32, Dc = 1. 447 Mg /cm3, F(000) = 980, (CuKa) = 1.54178 Å, mu = 2.883 mm-1, R = 0.0691 and wR = 0.1958 for 6420 observed reflections (I > 2s(I)). Importantly, the compound revealed potential anticancer activities in six cancer cells and could stimulate tubulin polymerization in vitro, indicating that the small-mol. could be selected as a lead compound for the development of microtubule stimulator. In the experiment, the researchers used many compounds, for example, Trimethylsulfoxonium iodide(cas: 1774-47-6COA of Formula: C3H9IOS)
Trimethylsulfoxonium iodide(cas: 1774-47-6) is a sulfoxonium salt. It is used to generate dimethyloxosulfonium methylide by reaction with sodium hydride. The latter compound is used as a methylene-transfer reagent, and is used to prepare epoxides.COA of Formula: C3H9IOS
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com