《One-Pot Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX): Process Safety Assessment and Impact of Impurities on Product Stability》 was published in Organic Process Research & Development in 2020. These research results belong to Hari, Durga Prasad; Caramenti, Paola; Schouwey, Lionel; Chang, Miyeon; Nicolai, Stefano; Bachert, Donald; Wright, Timothy; Orella, Chuck; Waser, Jerome. Product Details of 88-67-5 The article mentions the following:
The hypervalent iodine reagent I, 1-[(TriIsoPropylSilyl)Ethynyl]-1,2-BenziodoXol-3(1H)-one (TIPS-EBX) is among the most useful electrophilic and somophilic alkynylation reagents. Herein, we report a new synthetic protocol to access this reagent in one step from standard com. available reagents. Thermal anal. of the synthesis procedure showed only weak exotherms. The compound could be obtained with high purity and stability using this new protocol, but care had to be taken to remove tosylate salts impurities, as they led to a lower thermal stability. TIPS-EBX synthesized using the new procedure displayed no shock sensitivity. In the experiment, the researchers used 2-Iodobenzoic acid(cas: 88-67-5Product Details of 88-67-5)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Product Details of 88-67-5
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com