In 2019,Journal of the Iranian Chemical Society included an article by Gaikwad, D. S.; Undale, K. A.; Patil, D. B.; Pore, D. M.. Safety of 1-Iodo-4-methylbenzene. The article was titled 《Multi-functionalized ionic liquid with in situ-generated palladium nanoparticles for Suzuki, Heck coupling reaction: a comparison with deep eutectic solvents》. The information in the text is summarized as follows:
A new catalytic system for Suzuki and Heck coupling for the synthesis of biaryls and olefins I [R = H, 4-OMe, 4-C(O)Me, etc.; R1 = Ph, CO2Me, CN, etc.] was developed from multi-functionalized task specific ionic liquid and in situ formed palladium nanoparticles(PdNPs). These PdNPs were found size below 10 nm and exhibited a excellent catalytic activity in the cross-coupling of aryl halide without using external phosphine ligand. Along with electron deficient olefins, electron rich olefins were also undergo smooth reaction giving excellent yield. The results obtained in ionic liquid were compared with results obtained in deep eutectic solvents. Progress of reaction was found very smooth in ionic liquid rather than in deep eutectic solvents. The aqueous system containing ionic liquid along with PdNPs was recycled for seven times, without any significant loss.1-Iodo-4-methylbenzene(cas: 624-31-7Safety of 1-Iodo-4-methylbenzene) was used in this study.
1-Iodo-4-methylbenzene(cas: 624-31-7) undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid catalyzed by (Ni,Mg)3Si2O5(OH)4 solid-solution nanotubes loaded with palladium.Safety of 1-Iodo-4-methylbenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com