《Biodegradable and biocompatible radiopaque iodinated poly-3-hydroxy butyrate: synthesis, characterization and in vitro/in vivo X-ray visibility》 was published in Polymer Bulletin (Heidelberg, Germany) in 2020. These research results belong to Erol, Arzu; Rosberg, Derya B. Hazer; Hazer, Baki; Goncu, Beyza S.. Name: 4-Iodobenzoic acid The article mentions the following:
Some novel radiopaque biodegradable and biocompatible iodinated polymers based on poly-3-hydroxy butyrate (PHB) were obtained. Following the attachment of diethanol amine to PHB, the hydroxyl ends were capped with 4-iodobenzoic acid and 2,3,5-tri-iodobenzoic acid. In this manner, tri-novel radiopaque polymers were obtained. The resulting polymers were structurally characterized by NMR technique. They were evaluated with respect to their possible use as radiopaque implant biomaterials indicating X-ray visibility in a noninvasive manner using routine X-ray absorption imaging techniques. These polymers exhibited good radiopacity with conventional imaging X-ray techniques in vivo. Addnl., biocompatibility of these iodinated polymers was also evaluated. There were no signs of infection or abscess formation on the surgical area. These novel radiopaque PHBs should be promising biomaterials for a new-generation radiopaque materials. The results came from multiple reactions, including the reaction of 4-Iodobenzoic acid(cas: 619-58-9Name: 4-Iodobenzoic acid)
4-Iodobenzoic acid(cas: 619-58-9) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Name: 4-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com