The author of 《Ligand-Enabled PdII-Catalyzed Iterative γ-C(sp3)-H Arylation of Free Aliphatic Acid》 were Dolui, Pravas; Das, Jayabrata; Chandrashekar, Hediyala B.; Anjana, S. S.; Maiti, Debabrata. And the article was published in Angewandte Chemie, International Edition in 2019. Recommanded Product: 1-Iodo-4-methylbenzene The author mentioned the following in the article:
C-H functionalization of aliphatic carboxylic acids without attaching exogenous auxiliary has been so far limited at the proximal β-position. In this work, we demonstrate a ligand enabled palladium catalyzed first regioselective distal γ-C(sp3)-H functionalization of aliphatic carboxylic acids without incorporating an exogenous directing group. Aryl iodides containing versatile functional groups including complex organic mols. are well tolerated with good to excellent yields during the γ-C(sp3)-H arylation reaction. Interestingly, weak coordination of carboxylate group can be further extended for sequential hetero di-arylation. Application of the protocol has been showcased by synthesizing substituted α-tetralone. Mechanistic investigations have been carried out to shed light on the reaction pathway. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-4-methylbenzene(cas: 624-31-7Recommanded Product: 1-Iodo-4-methylbenzene)
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Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com