Safety of 4-IodopyridineIn 2022 ,《Synthesis of Thioalkynes by Desilylative Sonogashira Cross-Coupling of Aryl Iodides and 1-Methylthio-2-(trimethylsilyl)ethyne》 was published in European Journal of Organic Chemistry. The article was written by Cao, Yang; Huang, Yang; Blakemore, Paul R.. The article contains the following contents:
1-Methylthio-2-arylethynes ArC≡CSMe [Ar = Ph, 1-naphthyl, 4-MeC6H4, etc.] were prepared in typically good to excellent yields from aryl iodides and 1-methylthio-2-(trimethylsilyl)ethyne by a desilylative Sonogashira process employing Pd(PPh3)2Cl2 (1 mol %), CuI (10 mol %) and K2CO3 (6 equiv) in MeOH-Et3N-THF (1:2:2) at rt for 16 h (16 examples, 31-96% yield). Thienyl and pyridyl iodides (all regioisomers) were similarly converted to 1-methylthio-2-heteroarylethynes ArC≡CSMe [Ar = 2-pyridyl, 3-pyridyl, 4-pyridyl, 2-thienyl, 3-thienyl] (5 examples, 54-82% yield). The process was extended with similar results to comparable thioalkynes PhC≡CSR [R = n-Bu, cyclohexyl, 4-MeC6H4] substituted on sulfur. The experimental process involved the reaction of 4-Iodopyridine(cas: 15854-87-2Safety of 4-Iodopyridine)
4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Safety of 4-Iodopyridine
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com