《New V1a receptor antagonist. Part 2. Identification and optimization of triazolobenzazepines》 was written by Bozo, Eva; Baska, Ferenc; Lovei, Klara; Szanto, Gabor; Domany-Kovacs, Katalin; Kurko, Dalma; Szondine Kordas, Krisztina; Szokoli, Teodora; Bata, Imre. Safety of Trimethylsulfoxonium iodideThis research focused onvasopressin V1a antagonist HTS synthesis triazolobenzazepines; Antagonist; HTS; Synthesis; Triazolobenzazepines; V1a; Vasopressin. The article conveys some information:
Solid preclin. evidence links vasopressin to social behavior in animals, so, extensive work has been initiated to find new vasopressin V1a receptor antagonists which can improve deteriorated social behavior in humans and can treat the core symptoms of autistic behavior, as well. Our aim was to identify new chem. entities with antagonizing effects on vasopressin V1a receptors. Continuing our previous work, we found an in vitro and in vivo orally active V1a selective antagonist mol. (40) among [1,2,4]triazolo[4,3-a][1]benzazepines. In the experimental materials used by the author, we found Trimethylsulfoxonium iodide(cas: 1774-47-6Safety of Trimethylsulfoxonium iodide)
Trimethylsulfoxonium iodide(cas: 1774-47-6) reacts with sodium hydride to prepare dimethyloxosulfonium methylide, which is used as a methylene-transfer reagent in synthetic chemistry. It is used to prepare ylide, which reacts with carbonyl compounds to get epoxides.Safety of Trimethylsulfoxonium iodide
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com