Zhang, Nanjing; Turpoff, Anthony; Zhang, Xiaoyan; Huang, Song; Liu, Yalei; Almstead, Neil; Njoroge, F. George; Gu, Zhengxian; Graci, Jason; Jung, Stephen P.; Pichardo, John; Colacino, Joseph; Lahser, Fred; Ingravallo, Paul; Weetall, Marla; Nomeir, Amin; Karp, Gary M. published an article on January 15 ,2016. The article was titled 《Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.COA of Formula: C4H2FIN2 The information in the text is summarized as follows:
A novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides was identified and optimized for activity against the HCV genotype 1b replicon resulting in compounds with potent and selective activity. Further evaluation of this series demonstrated potent activity across HCV genotypes 1a, 2a and 3a. Compound I had reduced activity against HCV genotype 1b replicons containing single mutations in the NS4B coding sequence (F98C and V105M) indicating that NS4B is the target. This novel series of 2-(4-sulfonamidophenyl)-indole 3-carboxamides serves as a promising starting point for a pan-genotype HCV discovery program. After reading the article, we found that the author used 2-Fluoro-5-iodopyrimidine(cas: 697300-79-1COA of Formula: C4H2FIN2)
2-Fluoro-5-iodopyrimidine(cas: 697300-79-1) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.COA of Formula: C4H2FIN2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com