Rodriguez, Jose F.; Zhang, Anji; Bajohr, Jonathan; Whyte, Andrew; Mirabi, Bijan; Lautens, Mark published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Cycloisomerization of Carbamoyl Chlorides in Hexafluorisopropanol: Stereoselective Synthesis of Chlorinated Methylene Oxindoles and Quinolinones》.Safety of 4-Chloro-2-iodoaniline The article contains the following contents:
Hexafluorisopropanol (HFIP) was employed as an additive for the generation of 3-(chloromethylene)oxindoles I [R = n-Bu, (CH2)3CN, Ph, etc.; R1 = Me, cyclohexylmethyl, Bn, etc.; R2 = H, 5-Me, 5-F, etc.] via the chloroacylation of alkyne-tethered carbamoyl chlorides. This reaction avoided the use of a metal catalyst and accessed products in high yields and stereoselectivities. Addnl., this reaction was scalable and proved amenable to a series of product derivatizations, including the synthesis of nintedanib. The reactivity of alkene-tethered carbamoyl chlorides with hexafluorisopropanol (HFIP) was harnessed towards the synthesis of 2-quinolinones II [R3 = H, Me; R4 = Me, i-Pr, Ph; R5 = Me, CH2CH=CH2]. In the experimental materials used by the author, we found 4-Chloro-2-iodoaniline(cas: 63069-48-7Safety of 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Safety of 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com