Punjajom, Kunlayanee; Tummatorn, Jumreang; Ruchirawat, Somsak; Thongsornkleeb, Charnsak published their research in Asian Journal of Organic Chemistry in 2021. The article was titled 《PdCl2-Catalyzed Oxidative Cyclization of N-(2′-Alkynylaryl)-1,3-ketoamides: Synthesis of 3,4-Diacyl-2-Quinolones》.Computed Properties of C6H5ClIN The article contains the following contents:
3,4-Diacyl-2-quinolone derivatives were prepared in a rapid manner starting from N-(2′-alkynylaryl)-1,3-ketoamide substrates. The reaction showcased a mild radical process mediated by ceric ammonium nitrate (CAN) in the presence of 5 mol% PdCl2 under basic conditions and was applicable to a wide range of substrates, giving 3,4-diacyl-2-quinolone products in up to 91% yield in over 40 examples. The reaction proceeded via the generation of a radical intermediate which could be trapped as a TEMPO-adduct that was isolated and fully characterized. The reported method provided a practical and scalable synthetic access to densely functionalized 3,4-diacyl-2-quinolone derivatives which would be suitable for further applications including medicinal and bioactivity evaluations as well as synthetic transformations. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Computed Properties of C6H5ClIN)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Computed Properties of C6H5ClIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com