Polivkova, Jana; Piotrowski, David W. published the artcile< Stereodefined Cyclopentanes by Hydroarylation-Ring Opening>, Category: iodides-buliding-blocks, the main research area is stereodefined cyclopentane preparation; hydroarylation azabicycloheptenone nucleophilic ring opening.
The hydroarylation of 2-azabicyclo[2.2.1]hept-5-en-3-one followed by nucleophilic ring opening was employed as an operationally simple route to stereodefined trisubstituted cyclopentane analogs. This synthetic sequence was successfully executed using a variety of nucleophiles including hydroxide, alkoxide, hydride, Grignard reagents, and amines. E.g., hydroarylation of rac-2-azabicyclo[2.2.1]hept-5-en-3-one with PhI, followed by reaction with di-tert-Bu dicarbonate, gave 15% I and 25% II. Ring opening of II with LiOH in water gave 71% cyclopentane derivative (III). This methodol. facilitated the preparation of a constrained version of dipeptidylpeptidase 4 inhibitor sitagliptin.
Synthetic Communications published new progress about Diastereoselective synthesis. 2265-92-1 belongs to class iodides-buliding-blocks, and the molecular formula is C6H3F2I, Category: iodides-buliding-blocks.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com