Safety of 2-Iodobenzoic acidIn 2019 ,《Formation of Benzylic Iodides via a Nickel Catalyzed Diastereoselective Dearomative Carboiodination Reaction of Indoles》 was published in Angewandte Chemie, International Edition. The article was written by Marchese, Austin D.; Lind, Florian; Mahon, Aine E.; Yoon, Hyung; Lautens, Mark. The article contains the following contents:
A diastereoselective dearomative carboiodination reaction is reported. Herein, a novel metal-catalyzed approach for the preparation of reactive secondary benzylic iodides I (R1 = H, 8-Br, 9-Me, etc.; R2 = Me, Et, Ph, etc.; R3 = H, 2-OMe, 2-F) is reported. Utilizing the unique reactivity of nickel, the carboiodination reaction of non-activated aromatic double bonds provided a previously unattainable class of iodides. A broadly applicable method to avoid the use of a metallic reducing agent by utilizing an alkyl phosphite as the ligand has been discussed. The reaction is thought to proceed through a syn intramol. carbonickelation across 2-substituted indole, followed by a diastereoretentive reductive elimination of the carbon-iodine bond. The complex iodinated indolines generated in the reaction were obtained in moderate to good yields and good to excellent diastereoselectivity. The products were easily functionalized by a variety of synthetic methods. In the experiment, the researchers used many compounds, for example, 2-Iodobenzoic acid(cas: 88-67-5Safety of 2-Iodobenzoic acid)
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Safety of 2-Iodobenzoic acid Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com