Ivachtchenko, Alexandre; Golovina, Elena; Kadieva, Madina; Mitkin, Oleg; Tkachenko, Sergei; Okun, Ilya published their research in Bioorganic & Medicinal Chemistry on August 1 ,2013. The article was titled 《Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-HT6 receptors》.Quality Control of 1-Chloro-4-iodo-2-nitrobenzene The article contains the following contents:
Substituted di-Ph sulfones were synthesized, and the structures were confirmed by NMR, LC-MS and X-ray crystallog. Their antagonistic activities towards 5-HT6 receptor were assessed in a cell-based functional assay. Di-Ph sulfone, in spite of being the smallest and simplest known sulfonyl-containing 5-HT6R antagonist, showed a strong potency (Ki = 1.6 μM). Its derivative with a methylamine substituent, [N-methyl-2-(phenylsulfonyl)aniline], was ∼66-times as active as di-Ph sulfone (Ki = 24.3 nM). Addition of a piperazinyl moiety in the para-position relative to the sulfonyl group in N-methyl-2-(phenylsulfonyl)-5-piperazin-1-ylaniline led to a further 150-fold increase in potency (Ki = 0.16 nM) to block the serotonin-induced response of HEK-293 cells that were stably transfected with the human recombinant 5-HT6 receptor. In the experimental materials used by the author, we found 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Quality Control of 1-Chloro-4-iodo-2-nitrobenzene)
1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics.Quality Control of 1-Chloro-4-iodo-2-nitrobenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com