《Palladium-catalyzed Ugi-type reaction of 2-iodoanilines with isocyanides and carboxylic acids affording N-acyl anthranilamides》 was written by Yao, Tuanli; Wang, Bo; Ren, Beige; Qin, Xiangyang; Li, Tao. Recommanded Product: 4-Chloro-2-iodoaniline And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021. The article conveys some information:
The first palladium-catalyzed Ugi-type multicomponent reaction for the synthesis of N-acyl anthranilamides I (R = t-Bu, cyclohexyl, 2,6-dimethylphenyl, etc.; R1 = H, OMe, Cl, F, etc.; R2 = H, Cl, C(O)OMe; R3 = H, F, Cl; R4 = Me, Ph, thiophen-3-yl, etc.) from isocyanides RNC, 2-iodoanilines 2-I-4-R1-5-R2-6-R3C6HNH2 and carboxylic acids R4C(O)OH has been developed. This method provides expeditious and highly efficient access to structurally diverse N-acyl anthranilamides I from readily available starting materials with good functional group compatibility. The utility of this method has been demonstrated by the late stage functionalization of two com. drugs: Flurbiprofen and Loxoprofen. In the experiment, the researchers used 4-Chloro-2-iodoaniline(cas: 63069-48-7Recommanded Product: 4-Chloro-2-iodoaniline)
4-Chloro-2-iodoaniline(cas: 63069-48-7) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 4-Chloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com