In 2017,Chemical Communications (Cambridge, United Kingdom) included an article by Yang, Xinglin; Shan, Gang; Yang, Zimo; Huang, Guiyi; Dong, Guoqiang; Sheng, Chunquan; Rao, Yu. Related Products of 41252-95-3. The article was titled 《One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(II)-catalyzed cascade C(sp3)-H activations》. The information in the text is summarized as follows:
A novel approach toward quaternary carbon centered cyclobutanes through Pd(II)-catalyzed sequential intramol. methylene C-H alkylation and intermol. methine C-H bond arylation, alkenylation, alkylation, alkynylation, allylation, benzylation or alkoxylation is described. These quaternary carbon centered cyclobutanes could be further diversified through Pd(II)-catalyzed γ-C(sp3)-H bond activations. The synthetic utility of this novel approach was exemplified by its application to the synthesis of a bioactive small mol. Thus, e.g., cascade intramol. C-H alkylation/C-H arylation of 6-bromohexanamide containing the 8-aminoquinoline directing group (I) with 4-iodoacetophenone in presence of Pd(OAc)2/Ag2CO3 afforded cyclobutane II (75% isolated). In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Related Products of 41252-95-3)
1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Related Products of 41252-95-3
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com