Lin, Wenwei; Chen, Ling; Knochel, Paul published the artcile< Preparation of functionalized 3,4-pyridynes via 2-magnesiated diaryl sulfonates>, Name: 4-Iodopyridin-3-ol, the main research area is pyridyne preparation Diels Alder cycloaddition furan nucleophilic addition; pyridine arylsulfonyloxy halo preparation magnesiation elimination; oxaazatricycloundecatetraene preparation.
The preparation of functionalized 3,4-pyridynes as highly reactive intermediates has been achieved by the controlled elimination of readily generated magnesiated diaryl sulfonates obtained by a low temperature I/Mg- or Br/Mg-exchange starting from the corresponding halopyridines I (Ar = 4-ClC6H4; X = Br, iodo; R1 = H, Br, Me; R2 = Cl, iodo, MeO, H2C:CHCH2, PhS, 4-ClC6H4S, 4-EtO2CC6H4). After trapping with furan, moderate to good yields of the desired functionalized cycloadducts II were obtained. The addition of an (arylthio)magnesium chloride or (arylselenyl)magnesium chloride to 3,4-pyridyne followed by quenching with an electrophile is also described.
Tetrahedron published new progress about Alkynes, arynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Name: 4-Iodopyridin-3-ol.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com