Reference of 1-Chloro-4-iodo-2-nitrobenzeneOn October 31, 2016 ,《Pd-catalyzed coupling reaction of 6-hydroxy-2-(prop-2-yn-1-ylsulfanyl)pyrimidin-4(1H)-one with aryl iodides: efficient syntheses of new 3-benzylthiazolo[3,2-a]pyrimidinones》 appeared in Chemistry of Heterocyclic Compounds (New York, NY, United States). The author of the article were Keivanloo, Ali; Bakherad, Mohammad; Shahani, Taraneh; Amin, Amir Hossein. The article conveys some information:
An efficient synthetic protocol was developed for the preparation of 3-benzyl-7(5)-hydroxy-5(7)H-[1,3]thiazolo[3,2-a]pyrimidin-5(7)-ones from 6-hydroxy-2-(prop-2-yn-1-ylthio)pyrimidin-4(1H)-one and aryl iodides in the presence of Pd-Cu complex catalyst. This one-pot process provides a simple and direct method for the synthesis of new thiazolo[3,2-a]pyrimidinones in good to high yields. In the experiment, the researchers used 1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3Reference of 1-Chloro-4-iodo-2-nitrobenzene)
1-Chloro-4-iodo-2-nitrobenzene(cas: 41252-95-3) belongs to organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Reference of 1-Chloro-4-iodo-2-nitrobenzene Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com