Computed Properties of C5H4INIn 2021 ,《Steric Hindrance in Metal Coordination Drives the Separation of Pyridine Regioisomers Using Rhodium(II)-Based Metal-Organic Polyhedra》 was published in Angewandte Chemie, International Edition. The article was written by Hernandez-Lopez, Laura; Martinez-Esain, Jordi; Carne-Sanchez, Arnau; Grancha, Thais; Faraudo, Jordi; Maspoch, Daniel. The article contains the following contents:
The physicochem. similarity of isomers makes their chem. separation through conventional techniques energy intensive. Herein, we report that, instead of using traditional encapsulation-driven processes, steric hindrance in metal coordination on the outer surface of RhII-based metal-organic polyhedra (Rh-MOPs) can be used to sep. pyridine-based regioisomers via liquid-liquid extraction Through mol. dynamics simulations and wet experiments, we discovered that the capacity of pyridines to coordinatively bind to Rh-MOPs is determined by the positions of the pyridine substituents relative to the pyridine nitrogen and is influenced by steric hindrance. Thus, we exploited the differential solubility of bound and non-bound pyridine regioisomers to engineer liquid-liquid self-sorting systems. As a proof of concept, we separated four different equimol. mixtures of regioisomers, including a mixture of the industrially relevant compounds 2-chloropyridine and 3-chloropyridine, isolating highly pure compounds in all cases. In the part of experimental materials, we found many familiar compounds, such as 4-Iodopyridine(cas: 15854-87-2Computed Properties of C5H4IN)
4-Iodopyridine(cas: 15854-87-2) is a halogenated heterocycle that is a building block for proteomics research. 4-Iodopyridine is used as a reagent in the synthesis of indazolylamides as glucocorticoid receptor agonists.Computed Properties of C5H4IN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com