In 2022,Golebiewska, Justyna; Bartoszewicz, Agnieszka; Kalek, Marcin; Stawinski, Jacek published an article in Phosphorus, Sulfur and Silicon and the Related Elements. The title of the article was 《Second generation of nucleotide analogs》.Computed Properties of C4H4INO2 The author mentioned the following in the article:
The most common type of modification of a phosphorus center is the replacement of one or two non-bridging atoms of the phosphate group with different heteroatoms (e.g., sulfur, selenium) or groups of atoms (e.g., Me, borane). Such compounds are referred to as the first generation of nucleotide analogs, e.g. I. We were interested in exploring the possibility of further functionalizing of the heteroatoms present in nucleoside phosphorothioates, phosphoroselenoate or boranephosphonates to create a second generation of nucleotide analogs with hopefully new biol. properties. Here we report a preliminary account of our work on introducing addnl. modifications on the sulfur or selenium heteroatom of nucleotide analogs.1-Iodopyrrolidine-2,5-dione(cas: 516-12-1Computed Properties of C4H4INO2) was used in this study.
1-Iodopyrrolidine-2,5-dione(cas: 516-12-1) is used in the preparation of vinyl sulfones from olefins and benzenesulfinic acid. It acts as a source for I+ and involved in Hunsdiecker reactions for the conversion of cinnamic acids, and propiolic acids to the corresponding alfa-halostyrenes and 1-halo-1-alkynes respectively. Computed Properties of C4H4INO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com