《Nickel-Catalyzed Asymmetric Synthesis of α-Arylbenzamides》 was written by Cuesta-Galisteo, Sergio; Schoergenhumer, Johannes; Wei, Xiaofeng; Merino, Estibaliz; Nevado, Cristina. Computed Properties of C7H7IThis research focused onvinyl amide aryliodide nickel catalyst regioselective enantioselective reductive hydroarylation; chiral arylbenzamide preparation; asymmetric synthesis; hydroarylation; nickel; vinyl amides; α-aryl amides. The article conveys some information:
A nickel-catalyzed asym. reductive hydroarylation of vinyl amides to produce enantioenriched α-arylbenzamides is reported. The use of a chiral bisimidazoline (BIm) ligand, in combination with diethoxymethylsilane and aryl halides, enables the regioselective introduction of aryl groups to the internal position of the olefin, forging a new stereogenic center α to the N atom. The use of neutral reagents and mild reaction conditions provides simple access to pharmacol. relevant motifs present in anticancer, SARS-CoV PLpro inhibitors, and KCNQ channel openers. In the experiment, the researchers used many compounds, for example, 1-Iodo-4-methylbenzene(cas: 624-31-7Computed Properties of C7H7I)
1-Iodo-4-methylbenzene(cas: 624-31-7) is used in wide range of medicals industrial applications as well as in pharmaceutical intermediates, polarizing films for Liquid Crystal Display (LCD) chemicals.Computed Properties of C7H7I
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com