Name: 2-Iodobenzoic acidIn 2021 ,《Synthesis and evaluation of α-glucosidase inhibitory activity of sulfonylurea derivatives》 was published in Zeitschrift fuer Naturforschung, B: A Journal of Chemical Sciences. The article was written by Bui, Thi Thoi; Tran, Van Loc; Ngo, Dai Quang; Tran, Van Chien; Tran, Van Sung; Tran, Thi Phuong Thao. The article contains the following contents:
Two series of sulfonylureas derivatives include 24 compounds I (R = NH2, phenylamidyl, (3-methylpyridin-2-yl)amidyl, (quinoxalin-2-yl)amidyl, etc.) and II (R1 = OEt, cyclopentylaminyl, benzylaminyl, (2,3,4-trifluorophenyl)aminyl, etc.), among them, 17 new derivatives, have been synthesized and evaluated for their α-glucosidase inhibitory activity. Compounds I (R = (2E)-3-(4-hydroxyphenyl)prop-2-enamidyl; R = (2-hydroxy-3,5-diiodophenyl)amidyl) and II (R1 = [4-nitro-3-(trifluoromethyl)phenyl]aminyl) showed significant in vitro α-glucosidase inhibition with IC50 values of 5.58, 79.85 and 213.36μm, resp., comparing with the standard compounds acarbose (IC50 = 268.29μm) and glipizide (IC50 = 300.47μm). The preliminary structure-activity relationships (SARs) of the synthesized compounds I and II were also investigated.2-Iodobenzoic acid(cas: 88-67-5Name: 2-Iodobenzoic acid) was used in this study.
2-Iodobenzoic acid(cas: 88-67-5) belongs to organic iodides. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Name: 2-Iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com