Rahimidashaghoul, Kheironnesae; Klimankova, Iveta; Hubalek, Martin; Korecky, Michal; Chvojka, Matus; Pokorny, Daniel; Matousek, Vaclav; Fojtik, Lukas; Kavan, Daniel; Kukacka, Zdenek; Novak, Petr; Beier, Petr published the artcile< Reductant-induced free radical fluoroalkylation of nitrogen heterocycles and innate aromatic amino acid residues in peptides and proteins>, HPLC of Formula: 1391728-13-4, the main research area is peptides protein synthesis reductant induced free radical fluoroalkylation tryptophan; nitrogen heterocycle amino acid fluoroalkylation bioconjugation fluorine iodine radical; myoglobin ubiquitin human carbonic anhydrase functionalization mol modeling; fluoroalkylation reaction mechanism sodium ascorbate catalyst; bioconjugation; fluorine; iodine; radicals; tryptophan.
A series of fluoroalkylated cyclic λ3-iodanes and their hydrochloride salts was prepared and used in a combination with sodium ascorbate in buffer or aqueous methanol mixtures for radical fluoroalkylation of a range of substituted indoles, pyrroles, tryptophan or its derivatives, and Trp residues in peptides. As demonstrated on several peptides, the aromatic amino acid residues of Trp, Tyr, Phe, and His are targeted with high selectivity to Trp. The functionalization method is biocompatible, mild, rapid, and transition-metal-free. The proteins myoglobin, ubiquitin, and human carbonic anhydrase I were also successfully functionalized.
Chemistry – A European Journal published new progress about Fluoroalkylation. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, HPLC of Formula: 1391728-13-4.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com