Kiefl, Gabriel M.; Gulder, Tanja published the artcile< α-Functionalization of Ketones via a Nitrogen Directed Oxidative Umpolung>, Related Products of 1391728-13-4, the main research area is alpha functionalization pyridyl ketone oxidative umpolung hypervalent fluorine iodane; regioselective oxidative functionalization.
Reversing the polarity in mols. is a versatile tool for expanding the boundaries of structural space. Despite a manifold of different umpolung methods available today, overcoming the inherent reactivity still remains a constant challenge in organic chem. The oxidative α-functionalization of ketones by external nucleophiles constitute such an example. Herein, we present a hypervalent F-iodane mediated umpolung of pyridyl ketones triggered by Lewis base/Lewis acid noncovalent interactions. A wide variety of external nucleophiles are introduced with high regioselectivity applying this substrate-directing concept.
Journal of the American Chemical Society published new progress about Directing groups. 1391728-13-4 belongs to class iodides-buliding-blocks, and the molecular formula is C9H10FIO, Related Products of 1391728-13-4.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com