Boyle, Benjamin T.; Koniarczyk, J. Luke; McNally, Andrew published the artcile< Facile Pyridine SNAr Reactions via N-Phosphonium-Pyridinium Intermediates>, Safety of 4-Iodopyridin-3-ol, the main research area is pyridine nucleophilic aromatic substitution reaction halopyridine phosphine; phosphonium pyridinium intermediate; SNAr reaction; phosphonium salts; pyridines; pyridinium salts.
Here we report that N-phosphonium pyridinium intermediates are unusually reactive for pyridine SNAr reactions. Specifically, forming phosphonium salts from halopyridines typically requires elevated temperatures and Lewis acid additives. The alternative activation mode described in this paper permits C-P bond formation to occur at ambient temperatures in many cases, and functions across a broad range of substrates.
Synlett published new progress about Nucleophilic aromatic substitution reaction. 188057-20-7 belongs to class iodides-buliding-blocks, and the molecular formula is C5H4INO, Safety of 4-Iodopyridin-3-ol.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com