Month: September 2022

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Recommanded Product: 3-Iodoaniline.

Asahara, Haruyasu;Mukaijo, Yusuke;Muragishi, Kengo;Iwai, Kento;Ito, Akitaka;Nishiwaki, Nagatoshi research published 《 Metal-Free and syn-Selective Hydrohalogenation of Alkynes through a Pseudo-Intramolecular Process》, the research content is summarized as follows. A new metal-free hydrohalogenation method for alkynes was developed, which proceeded through a pseudo-intramol. process. In this reaction, ethynylaniline served as a substrate to quant. form an anilinium salt upon treatment with hydrochloric acid. The spatial proximity facilitated the efficient electrophilic addition of HCl to the ethynyl group in syn-mode, affording the corresponding chloroalkene without overaddn. This protocol was applied to HBr and HI, and the corresponding bromo- and iodoalkenes were obtained, resp. The obtained chloroalkene was converted to tri-substituted alkenes possessing different aryl/alkynyl groups through Pd-catalyzed cross-coupling reactions.

626-01-7, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., Recommanded Product: 3-Iodoaniline

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Synthetic Route of 144-48-9.

Arsiccio, Andrea;Metcalfe, Clive;Pisano, Roberto;Raut, Sanj;Coxon, Carmen research published 《 A proximity-based in silico approach to identify redox-labile disulfide bonds: The example of FVIII》, the research content is summarized as follows. Allosteric disulfide bonds permit highly responsive, transient ‘switch-like’ properties that are ideal for processes like coagulation and inflammation that require rapid and localised responses to damage or injury. Haemophilia A (HA) is a rare bleeding disorder managed with exogenous coagulation factor(F) VIII products. FVIII has eight disulfide bonds and is known to be redox labile, but it is not known how reduction/oxidation affects the structure-function relationship, or its immunogenicity-a serious complication for 30% severe HA patients. Understanding how redox-mediated changes influence FVIII can inform mol. engineering strategies aimed at improving activity and stability, and reducing immunogenicity. FVIII is a challenging mol. to work with owing to its poor expression and instability so, in a proof-of-concept study, we used mol. dynamics (MD) to identify which disulfide bonds were most likely to be reduced and how this would affect structure/function; results were then exptl. verified. MD identified Cys1899-Cys1903 disulfide as the most likely to undergo reduction based on energy and proximity criteria. Further MD suggested this reduction led to a more open conformation. Here we present our findings and highlight the value of MD approaches.

Synthetic Route of 144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Product Details of C6H6IN.

Ariawan, Daryl;Au, Carol;Paric, Esmeralda;Fath, Thomas;Ke, Yazi D.;Kassiou, Michael;van Eersel, Janet;Ittner, Lars M. research published 《 The nature of diamino linker and halogen bonding define selectivity of pyrrolopyrimidine-based LIMK1 Inhibitors》, the research content is summarized as follows. The LIM-domain kinase (LIMK) family consists of two isoforms, LIMK1 and LIMK2, which are highly homologous, making selective inhibitor development challenging. LIMK regulates dynamics of the actin cytoskeleton, thereby impacting many cellular functions including cell morphol. and motility. Here, we designed and synthesized analogs of a known pyrrolopyrimidine LIMK inhibitor with moderate selectivity for LIMK1 over LIMK2 to gain insights into which features contribute to both activity and selectivity. We incorporated a different stereochem. around a cyclohexyl central moiety to achieve better selectivity for different LIMK isoforms. Inhibitory activity was assessed by kinase assays, and biol. effects in cells were determined using an in vitro wound closure assay. Interestingly, a slight change in stereochem. alters LIMK isoform selectivity. Finally, a docking study was performed to predict how the new compounds interact with the target.

Product Details of C6H6IN, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.

3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. HPLC of Formula: 144-48-9.

Antoci, Vasilichia;Oniciuc, Liliana;Amariucai-Mantu, Dorina;Moldoveanu, Costel;Mangalagiu, Violeta;Amarandei, Andreea Madalina;Lungu, Claudiu N.;Dunca, Simona;Mangalagiu, Ionel I.;Zbancioc, Gheorghita research published 《 Benzoquinoline derivatives: a straightforward and efficient route to antibacterial and antifungal agents》, the research content is summarized as follows. Herein the design, synthesis and exptl. and in silico evaluation of the antibacterial and antifungal activity of some new benzo[f]quinoline derivatives are reported. Two classes of benzo[f]quinolinium derivatives, benzo[f]quinolinium salts (BQS) I (R = H₂N, X = I; R = MeO, Me, t-Bu, Ph, etc., X = Br) and pyrrolobenzo[f]quinolinium cycloadducts (PBQC) II (R = Et, Ph; R¹ = H, MeO₂C), were designed and obtained in one or two steps via a direct and facile procedure: quaternization of benzo[f]quinoline with α-halo carbonyl compounds followed by a cycloaddition reaction. The antimicrobial assay revealed that the BQS salts I have an excellent quasi-nonselective antifungal activity against the fungus Candida albicans (some of them higher that the control drug nystatin) and very good antibacterial activity against the Gram pos. bacterium Staphylococcus aureus. The PBQC compounds II were inactive. Anal. of the biol. data revealed interesting SAR correlations in the benzo[f]quinolinium series of compounds The in silico studies furnished important data concerning the pharmacodynamics, pharmacokinetics and ADMET parameters of the BQS salts I. Studies of the interaction of each BQS salts with ATP synthase in the formed complex, reveal that salts I (R = 4-MeOC₆H₄, 4-PhC₆H₄, 4-ClC₆H₄; X = Br) have the best fit in a complex with ATP synthase. Study of the interaction of each BQS salts I with TOPO II in the formed complex reveals that salts I (R = 4-PhC₆H₄, 4-ClC₆H₄; X = Br) have the best-fit in complex with TOPO II. The in silico ADMET studies reveal that the compounds I have excellent drug-like properties, including a low toxicity profile. Overall, the exptl. and in silico studies indicate that compounds (R = Et, t-Bu, 4-MeOC₆H₄, 4-PhC₆H₄, 4-ClC₆H₄; X = Br) are promising leading drug candidates.

144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., HPLC of Formula: 144-48-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Product Details of C5H4IN.

Andresini, Michael;Spennacchio, Mauro;Colella, Marco;Losito, Gianluca;Aramini, Andrea;Degennaro, Leonardo;Luisi, Renzo research published 《 Sulfinimidate Esters as an Electrophilic Sulfinimidoyl Motif Source: Synthesis of N-Protected Sulfilimines from Grignard Reagents》, the research content is summarized as follows. In this work the reactivity of sulfinimidate esters as an electrophilic sulfinimidoyl motif source was investigated, for the first time. The reaction of such sulfinimidate esters with Grignard reagents enables the preparation of protected sulfilimines I [R¹ = Ph, 4-ClC₆H₄, 3-MeOC₆H₄, etc.; R² = Me, i-Pr, Ph, etc.] in high yields and with a remarkable structural variability. Moreover, the transformation could be performed in CPME (cyclopentyl Me ether) as a green solvent under environmentally responsible conditions.

Product Details of C5H4IN, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Name: 2-Iodoacetamide.

Alfaro, Javier Antonio;Bohlander, Peggy;Dai, Mingjie;Filius, Mike;Howard, Cecil J.;van Kooten, Xander F.;Ohayon, Shilo;Pomorski, Adam;Schmid, Sonja;Aksimentiev, Aleksei;Anslyn, Eric V.;Bedran, Georges;Cao, Chan;Chinappi, Mauro;Coyaud, Etienne;Dekker, Cees;Dittmar, Gunnar;Drachman, Nicholas;Eelkema, Rienk;Goodlett, David;Hentz, Sebastien;Kalathiya, Umesh;Kelleher, Neil L.;Kelly, Ryan T.;Kelman, Zvi;Kim, Sung Hyun;Kuster, Bernhard;Rodriguez-Larrea, David;Lindsay, Stuart;Maglia, Giovanni;Marcotte, Edward M.;Marino, John P.;Masselon, Christophe;Mayer, Michael;Samaras, Patroklos;Sarthak, Kumar;Sepiashvili, Lusia;Stein, Derek;Wanunu, Meni;Wilhelm, Mathias;Yin, Peng;Meller, Amit;Joo, Chirlmin research published 《 The emerging landscape of single-molecule protein sequencing technologies》, the research content is summarized as follows. Single-cell profiling methods have had a profound impact on the understanding of cellular heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, single-cell profiling of proteomes is not yet established. Here we describe new single-mol. protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell profiling. These technologies will in turn facilitate biol. discovery and open new avenues for ultrasensitive disease diagnostics.

Name: 2-Iodoacetamide, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.

2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., 144-48-9.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. COA of Formula: C5H4IN.

Alexander, J. R.;Kevorkian, P. V.;Topczewski, J. J. research published 《 Intercepting the Banert cascade with nucleophilic fluorine: direct access to α-fluorinated NH-1,2,3-triazoles》, the research content is summarized as follows. The treatment of propargylic azides RCCC(R¹R²)N₃ (R = Ph, pyridin-3-yl, 4-cyanophenyl, etc.; R¹ = H, Me, Et, Bn; R² = H, Me) with silver(I) fluoride in acetonitrile was found to yield α-fluorinated NH-1,2,3-triazoles I via the Banert cascade. The reaction was regioselective and the products result from an initial [3,3] rearrangement. The reaction is demonstrated on >15 examples with yields ranging from 37% to 86%.

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., COA of Formula: C5H4IN

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. HPLC of Formula: 5029-67-4.

Akiyama, Toshiki;Wada, Yuki;Yamada, Makito;Shio, Yasunori;Honma, Tetsuo;Shimoda, Shuhei;Tsuruta, Kazuki;Tamenori, Yusuke;Haneoka, Hitoshi;Suzuki, Takeyuki;Harada, Kazuo;Tsurugi, Hayato;Mashima, Kazushi;Hasegawa, Jun-ya;Sato, Yoshihiro;Arisawa, Mitsuhiro research published 《 Self-Assembled Multilayer Iron(0) Nanoparticle Catalyst for Ligand-Free Carbon-Carbon/Carbon-Nitrogen Bond-Forming Reactions》, the research content is summarized as follows. Self-assembled multilayer iron(0) nanoparticles (NPs, 6-10 nm), namely, sulfur-modified Au-supported Fe(0) [SAFe(0)], were developed for ligand-free one-pot carbon-carbon/carbon-nitrogen bond-forming reactions. SAFe(0) was successfully prepared using a well-established metal-nanoparticle catalyst preparative protocol by simultaneous in situ metal NP and nanospace organization (PSSO) with 1,4-bis(trimethylsilyl)-1,4-dihydropyrazine (Si-DHP) as a strong reducing agent. SAFe(0) was easy to handle in air and could be recycled with a low iron-leaching rate in reaction cycles.

HPLC of Formula: 5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., 5029-67-4.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Related Products of 1120-90-7.

Adler, Pauline;Dumas, Timothe;Deyris, Pierre-Alexandre;Petit, Eddy;Diliberto, Sebastien;Boulanger, Clotilde;Grison, Claude research published 《 II- from ecological recycling of Pd to greener sonogashira cross-coupling reactions》, the research content is summarized as follows. Based on a new process derived from biosorption technol. that uses roots from aquatic and wetland plants (Mentha aquatica, Eichhornia crassipes, Pistia stratiotes, Ludwigia peploides, Fallopia japonica), materials rich in lignin (pinecone, bark pine) and wastes rich in tannins (coffee grounds), we were able to prepare a new class of ecocatalyst, called Eco-Pd. The formed Eco-Pd are characterized via MP-AES and XRDP in the order to elucidate the chem. composition and the structure of the new formed materials. Interestingly, the presence of higher-oxidation-state palladium species, namely K₂PdCl₆, is observed We describe the use of this new generation of Eco-Pd for a green and sustainable Sonogashira reaction. The absence of copper, ligands, additives, a lower Pd loading (0.05 mol% – 0.1 mol%), the use of green solvents (glycerol/n-BuOH), and the use of biosourced Pd and base (Eco-Ca), are significant advantages of this approach. The combination TON/TOF (103/250 h^-1) can be advantageously compared with literature and demonstrates the remarkable practical utility of these new catalysts. Most importantly, the Eco-Pd can be easily recycled by biosorption and reused, that is another asset in terms of sustainable Chem.

1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Related Products of 1120-90-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 5029-67-4, formula is C5H4IN, Name is 2-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Quality Control of 5029-67-4.

Adenot, Aurelien;Anthore-Dalion, Lucile;Nicolas, Emmanuel;Berthet, Jean-Claude;Thuery, Pierre;Cantat, Thibault research published 《 A Copper(I)-Catalyzed Sulfonylative Hiyama Cross-Coupling》, the research content is summarized as follows. An air-tolerant Cu-catalyzed sulfonylative Hiyama cross-coupling reaction enabling the formation of diaryl sulfones is described. Starting from aryl silanes, DABSO and aryliodides, the reaction tolerates a large variety of polar functional groups (amines, ketones, esters, aldehydes). Control experiments coupled with DFT calculations shed light on the mechanism, characterized by the formation of a Cu(I)-sulfinate intermediate via fast insertion of a SO₂ mol.

5029-67-4, 2-Iodopyridine can be synthesized from 2-chloropyridine or 2-bromopyridine via treatment with iodotrimethylsilane.
2-Iodopyridine, also known as 2-Iodopyridine, is a useful research compound. Its molecular formula is C5H4IN and its molecular weight is 205 g/mol. The purity is usually 95%.
2-Iodopyridine is a halogenated building block. It is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
2-Iodopyridine is a white crystalline solid that is soluble in water, alcohol, and ether. The molecule contains a methyl group and two iodine atoms. 2-Iodopyridine has several industrial uses. It acts as a precursor to various pharmaceuticals and agrochemicals. The compound also exhibits insulin resistance properties, which may be related to its ability to bind to the insulin receptor and inhibit insulin signaling. 2-Iodopyridine can also be used for treating cancer because it binds to the DNA of cancer cells, preventing replication and leading to cell death.
2-Iodopyridine is a reagent used in the preparation of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors., Quality Control of 5029-67-4

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com