Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. Product Details of C5H4IN.
Li, Xiong;Xu, Jie;Li, Yue;Kramer, Soeren;Skrydstrup, Troels;Lian, Zhong research published 《 Silylcarboxylic Acids as Bifunctional Reagents: Application in Palladium-Catalyzed External-CO-Free Carbonylative Cross-Coupling Reactions》, the research content is summarized as follows. A palladium-catalyzed external-CO-free carbonylative Hiyama-Denmark cross-coupling reaction is presented. The introduction of silylcarboxylic acids I (R = 4-Me, 3-Me, 2-Me, 4-tert-butyl) as bifunctional reagents (CO and nucleophile source) avoids the need for external gaseous CO and a silylarene coupling partner. The transformation features high functional group tolerance and it is successful with electron-rich, -neutral, and -poor aryl iodides ArI (Ar = 4-methoxyphenyl, naphthalen-1-yl, thiophen-3-yl, etc.). Stoichiometric studies and control experiments provide insight into the reaction mechanism and support the hypothesized dual role of silylcarboxylic acids.
Product Details of C5H4IN, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.
3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.
3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com