Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Product Details of C5H4IN.
Li, Kejie;Wang, Ming;Jiang, Xuefeng research published 《 Full-spectrum fluoromethyl sulfonation via modularized multicomponent coupling》, the research content is summarized as follows. Modular free-assembly construction of mono-, di-, and tri-fluoromethyl sulfones was comprehensively achieved by a combination of halides, a sulfur dioxide surrogate, and halofluorocarbons. The industrial raw material thiourea dioxide served as the sulfur dioxide source, combined with readily available fluorocarbon sources such as 2-bromo-2-fluoroacetate and chlorodifluoromethane employed as fluoromethyl reagents. Notably, four Me sulfone-containing pharmaceuticals were modified into three types of fluoromethyl sulfones, displaying their great potential for drug discovery via the current strategy. Mechanistic studies further demonstrated that C-F···H-N interactions between thiourea dioxide and halofluorocarbons play a key role in stabilizing monofluoromethyl electrophiles and difluorocarbene species.
Product Details of C5H4IN, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.
3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.
3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com