Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Safety of 3-Iodopyridine.
Lee, Jaehee;Ju, Xuan;Lee, Miseon;Jiang, Qi;Jang, Hwanjong;Kim, Wan Shin;Wu, Linglin;Williams, Suja;Wang, Xiao-Jun;Zeng, Xingzhong;Payne, Jenna;Han, Zhengxu S. research published 《 Copper Catalyzed Regioselective and Stereospecific Aziridine Opening with Pyridyl Grignard Nucleophiles》, the research content is summarized as follows. Copper catalyzed regioselective and stereospecific coupling between aziridines and in-situ generated pyridine Grignard reagents was reported. This method provided β-pyridylethylamines with diverse structures and functionalities from aziridines and iodopyridines. The β-pyridylethylamines were potential scaffolds for the synthesis of biol. active compounds often found in pharmaceuticals. The synthesis of challenging chiral dihydroazaindoles was also achieved through mild one-pot reaction conditions via aziridine opening followed by nucleophilic cyclization.
Safety of 3-Iodopyridine, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.
3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.
3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com