Diaz, Jose Luis team published research on Journal of Medicinal Chemistry in 2021 | 1120-90-7

Quality Control of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

In everyday life, iodide is most commonly encountered as a component of iodized salt, which many governments mandate. 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Worldwide, iodine deficiency affects two billion people and is the leading preventable cause of intellectual disability. Quality Control of 1120-90-7.

Diaz, Jose Luis;Cuevas, Felix;Oliva, Ana I.;Font, Daniel;Sarmentero, M. Angeles;Alvarez-Bercedo, Paula;Lopez-Valbuena, Jose M.;Pericas, Miquel A.;Enrech, Raquel;Montero, Ana;Yeste, Sandra;Vidal-Torres, Alba;Alvarez, Ines;Perez, Pilar;Cendan, Cruz Miguel;Cobos, Enrique J.;Vela, Jose Miguel;Almansa, Carmen research published 《 Tricyclic Triazoles as σ1 Receptor Antagonists for Treating Pain》, the research content is summarized as follows. The synthesis and pharmacol. activity of a new series of 5a,7,8,8a-tetrahydro-4H,6H-pyrrolo[3,4-b][1,2,3]triazolo[1,5-d][1,4]oxazine derivatives I (R = benzyl, (4-fluorophenyl)methyl, oxan-4-ylmethyl, (1-methyl-1H-imidazol-2-yl)methyl, etc.; R1 = 2-fluorophenyl, 1-methylpiperidin-4-yl, pyrimidin-2-yl, etc.) as potent sigma-1 receptor (σ1R) ligands are reported. A lead optimization program aimed at improving the aqueous solubility of parent racemic nonpolar derivatives led to the identification of several σ1R antagonists with a good absorption, distribution, metabolism, and excretion in vitro profile, no off-target affinities, and characterized by a low basic pKa (around 5) that correlates with high exposure levels in rodents. Two compounds displaying a differential brain-to-plasma ratio distribution profile, I (R = (6-methoxypyridin-3-yl)methyl, R1 = 2-fluorophenyl; R = oxan-4-yl, R1 = 5-fluoropyridin-2-yl), exhibited a good analgesic profile and were selected as preclin. candidates for the treatment of pain.

Quality Control of 1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.

3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.

3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., 1120-90-7.

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com