Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons-Smith reaction (cyclopropanation using iodomethane), 1120-90-7, formula is C5H4IN, Name is 3-Iodopyridine. Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction. Quality Control of 1120-90-7.
Dhital, Raghu N.;Sen, Abhijit;Hu, Hao;Ishii, Rikako;Sato, Takuma;Yashiroda, Yoko;Kimura, Hiromi;Boone, Charles;Yoshida, Minoru;Futamura, Yushi;Hirano, Hiroyuki;Osada, Hiroyuki;Hashizume, Daisuke;Uozumi, Yasuhiro;Yamada, Yoichi M. A. research published 《 Phenylboronic Ester-Activated Aryl Iodide-Selective Buchwald-Hartwig-Type Amination toward Bioactivity Assay》, the research content is summarized as follows. A phenylboronic ester-activated aryl iodide-selective Buchwald-Hartwig-type amination was developed. When the reaction of aryl iodides and aryl/aliphatic amines using Ni(acac)2 was carried out in the presence of phenylboronic ester, the Buchwald-Hartwig-type amination proceeds smoothly to afford the corresponding amines RNHR1 [R = Ph, 2-MeC6H4, 4-BrC6H4, etc.; R1 = 4-MeC6H4, 4-ClC6H4, 3-pyridyl, etc.] in high yields. This reaction did not proceed in the absence of phenylboronic ester. A wide variety of aryl iodides could be applied in the presence of aryl chlorides and bromides, which remain intact during the reaction. The mechanistic studies of this reaction suggest that the phenylboronic ester acts as an activator for the amines to form the “ate complex”. Chem. kinetics studies showed that the reaction of aryl iodides, base and Ni(acac)2 follows first-order kinetics, while that of amines and phenylboronic ester follows zero-order kinetics. The bioactivity screening of the corresponding products showed that some amination products exhibit antifungal activity.
1120-90-7, 3-Iodopyridine is a heteroaryl halide. It undergoes microwave-assisted coupling with heterocyclic compounds (pyrazole, imidazole, pyrrole and indole) to afford the corresponding N-3-pyridinyl-substituted heterocyclic compounds.
3-Iodopyridine is a useful research chemical used as a reactant in the copper-catalyzed coupling of alkylamines and aryl iodides.
3-Iodopyridine is an isomeric compound that can be synthesized by cross-coupling reactions. This compound has been shown to have nicotinic acetylcholine receptor binding properties and may be useful in the treatment of Alzheimer’s disease. 3-Iodopyridine is a primary amino acid that can be used for the synthesis of amines, which are nitrogen nucleophiles. It has been crystallized with halides and its x-ray structures have been determined. The nmr spectra of 3-iodopyridine show that it contains phosphorus and nitrogen atoms. 3-Iodopyridine is also able to take up nitrate ions from solution, which may be due to its uptake properties., Quality Control of 1120-90-7
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com