Organic iodides are used in veterinary products (Organic Iodide Powder) as a nutritional source of iodine. 626-01-7, formula is C6H6IN, Name is 3-Iodoaniline. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs. Formula: C6H6IN.
Deng, Yaqi;Pi, Rou;Niu, Li;Zhao, Yun;Ni, Dan;Song, Longlong;Li, Zi;Han, Wangyujing;Wei, Qinghua;Han, Yuqiao;Zhu, Tong;Luo, Zhengli;Sun, Donghui;Dong, Suzhen;Liu, Shunying research published 《 Novel 2-phenyl-3-(Pyridin-2-yl) thiazolidin-4-one derivatives as potent inhibitors for proliferation of osteosarcoma cells in vitro and in vivo》, the research content is summarized as follows. Due to unknown pathogenesis and unidentified drug target, no drug for the treatment of osteosarcoma (OS) has been launched to the market. Herein, thiazolidinone 3-Fluoro-5-(3-(2-methoxyphenyl)-4-oxothiazolidin-2-yl)-N-(4-phenylbutyl) benzamide was discovered as a hit compound by phenotypic screening with an inhouse patrimonial collection of structural diversity. The following SAR (Structure-Activity Relationship) study affords the final water-soluble lead compound (R)-3-(3-(4-methylpyridin-2-yl)-4-oxothiazolidin-2-yl)-N-(4-(1H-pyrazol-1-yl) butyl) benzamide as a potential inhibitor for the proliferation of OS cells by the modulation of solubility of the compounds with remarkable cellular potency (IC50 = 21.9 nM for MNNG/HOS cells) and in vivo efficacy (52.9% inhibition OS growth in mice), as well as pharmacokinetic properties. (R)-3-(3-(4-methylpyridin-2-yl)-4-oxothiazolidin-2-yl)-N-(4-(1H-pyrazol-1-yl) butyl) benzamide also significantly suppresses OS cell migration in vitro and showed to be well-tolerated. Our preliminary investigation shows that the effects of (R)-3-(3-(4-methylpyridin-2-yl)-4-oxothiazolidin-2-yl)-N-(4-(1H-pyrazol-1-yl) butyl) benzamide are not dependent on p53 and myoferlin (MYOF). These results suggest that (R)-3-(3-(4-methylpyridin-2-yl)-4-oxothiazolidin-2-yl)-N-(4-(1H-pyrazol-1-yl) butyl) benzamide might be a potential drug candidate for OS treatment.
Formula: C6H6IN, 3-Iodoaniline is a useful research compound. Its molecular formula is C6H6IN and its molecular weight is 219.02 g/mol. The purity is usually 95%.
3-Iodoaniline is a fatty acid that is used in analytical methods to measure the concentration of human serum in blood. It can be used to estimate the population growth rate, with a half-life of about 13 hours. 3-Iodoaniline reacts with hydrogen bond and proton to form a reaction solution, which can be catalyzed by palladium-catalyzed coupling and suzuki coupling reactions. The activation energies for these reactions are typically in the range of 4-8 kcal/mol. The chemical ionization technique is a type of mass spectrometry that is used to determine kinetic data for this compound. Hydrochloric acid can be added as an acid catalyst to increase the rate of reaction and generate more accurate kinetic data., 626-01-7.
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com