Iodide is one of the largest monatomic anions. It is assigned a radius of around 206 picometers. 144-48-9, formula is C2H4INO, Name is 2-Iodoacetamide.For comparison, the lighter halides are considerably smaller: bromide (196 pm), chloride (181 pm), and fluoride (133 pm). In part because of its size, iodide forms relatively weak bonds with most elements. HPLC of Formula: 144-48-9.
Antoci, Vasilichia;Oniciuc, Liliana;Amariucai-Mantu, Dorina;Moldoveanu, Costel;Mangalagiu, Violeta;Amarandei, Andreea Madalina;Lungu, Claudiu N.;Dunca, Simona;Mangalagiu, Ionel I.;Zbancioc, Gheorghita research published 《 Benzoquinoline derivatives: a straightforward and efficient route to antibacterial and antifungal agents》, the research content is summarized as follows. Herein the design, synthesis and exptl. and in silico evaluation of the antibacterial and antifungal activity of some new benzo[f]quinoline derivatives are reported. Two classes of benzo[f]quinolinium derivatives, benzo[f]quinolinium salts (BQS) I (R = H2N, X = I; R = MeO, Me, t-Bu, Ph, etc., X = Br) and pyrrolobenzo[f]quinolinium cycloadducts (PBQC) II (R = Et, Ph; R1 = H, MeO2C), were designed and obtained in one or two steps via a direct and facile procedure: quaternization of benzo[f]quinoline with α-halo carbonyl compounds followed by a cycloaddition reaction. The antimicrobial assay revealed that the BQS salts I have an excellent quasi-nonselective antifungal activity against the fungus Candida albicans (some of them higher that the control drug nystatin) and very good antibacterial activity against the Gram pos. bacterium Staphylococcus aureus. The PBQC compounds II were inactive. Anal. of the biol. data revealed interesting SAR correlations in the benzo[f]quinolinium series of compounds The in silico studies furnished important data concerning the pharmacodynamics, pharmacokinetics and ADMET parameters of the BQS salts I. Studies of the interaction of each BQS salts with ATP synthase in the formed complex, reveal that salts I (R = 4-MeOC6H4, 4-PhC6H4, 4-ClC6H4; X = Br) have the best fit in a complex with ATP synthase. Study of the interaction of each BQS salts I with TOPO II in the formed complex reveals that salts I (R = 4-PhC6H4, 4-ClC6H4; X = Br) have the best-fit in complex with TOPO II. The in silico ADMET studies reveal that the compounds I have excellent drug-like properties, including a low toxicity profile. Overall, the exptl. and in silico studies indicate that compounds (R = Et, t-Bu, 4-MeOC6H4, 4-PhC6H4, 4-ClC6H4; X = Br) are promising leading drug candidates.
144-48-9, 2-Iodoacetamide is a synthetic retinoid that binds to the DNA of cells, altering transcription. It also has been found to be effective in treating bowel disease and has been shown to have dna binding activity. The compound was synthesized by attaching iodine molecules to acetamide. 2-Iodoacetamide targets the protein thiols on the surface of cells, which are responsible for oxidation and damage due to reactive oxygen species (ROS). This compound is metabolized by alcohol dehydrogenase and can be used as a biological sample or natural compound is a compound used as an electrophile for covalent modification of nucleophilic residues on proteins (cysteine, methionine, histidine). When modifying the active-site residues of cysteine proteases, α-Iodoacetamide acts as an irreversible inhibitor of these enzymes.
2-Iodoacetamide used in peptide mapping because it covalently binds with thiols in cysteine residues, thereby preventing disulfide bond formation. By virtue of reaction with cysteine, it is an irreversible inhibitor of enzymes with cysteine at the active site. Also reacts with histidine residues though much more slowly, and this activity is responsible for inhibition of ribonuclease.
An alkylating sulfhydryl reagent. Its actions are similar to those of iodoacetate., HPLC of Formula: 144-48-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com