In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of a novel class of potent and orally bioavailable sphingosine 1-phosphate receptor 1 antagonists, published in 2012-02-09, which mentions a compound: 138775-03-8, mainly applied to amide preparation sphingosine phosphate receptor antagonistic pharmacokinetics, Recommanded Product: (S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid.
A series of subtype selective sphingosine 1-phosphate receptor 1 (S1P1) antagonists are disclosed. Our high-throughput screening campaign revealed hit I for which an increase in potency and mouse oral exposure was achieved with minor modifications to the chem. scaffold. In vivo efficacy revealed that at high doses compounds II(X = F, Cl) inhibited tumor growth. Further optimization of our lead series led to the discovery of proline derivatives III(R = 1,2,3-triazol-1yl) (XL541) and III(R = 1,2,3-triazol-2yl) which had similar efficacy as our first generation analogs at significantly lower doses. Analog III(R = 1,2,3-triazol-1yl) displayed excellent pharmacokinetics and oral exposure in multiple species.
After consulting a lot of data, we found that this compound(138775-03-8)Recommanded Product: (S)-4-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)piperazine-2-carboxylic acid can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com