The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (2S)-(+)-3-Chloropropane-1,2-diol( cas:60827-45-4 ) is researched.HPLC of Formula: 60827-45-4.Lee, Yae Won; Yang, Hee Chun; Kim, Geon-Joong published the article 《Synthesis of highly enantiomerically enriched arenesulfonic acid 2-hydroxy esters via kinetic resolution of terminal epoxides》 about this compound( cas:60827-45-4 ) in Kongop Hwahak. Keywords: arenesulfonic acid hydroxy ester synthesis highly enantiomerically kinetic resolution. Let’s learn more about this compound (cas:60827-45-4).
This paper describes the very efficient and highly enantioselective ring opening of terminal epoxides with alkyl and arene sulfonic acid. The dinuclear chiral (salen) Co complexes bearing Lewis acids of Al, Ga and In catalyze the reaction enantioselectively in the presence of tetrabutylammonium chloride using tert-Bu Me ether as a solvent. The variation of the anion of the tetra Bu ammonium salt has significant impact on the reactivity and selectivity of the asym. ring opening of Ph glycidyl ether with p-toluenesulfonic acid. The order of reactivity and selectivity was found to be Cl- > l- > Br- > OH-. Strong synergistic effects of the different Lewis acid centers of Co-Al, Co-Ga and Co-In complexes were observed in the catalytic process. The dinuclear chiral salen catalyst containing AlCl3 was found to be most active and highly enantioselective (91% ee).
After consulting a lot of data, we found that this compound(60827-45-4)HPLC of Formula: 60827-45-4 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com