Extracurricular laboratory: Synthetic route of 60827-45-4

Although many compounds look similar to this compound(60827-45-4)Name: (2S)-(+)-3-Chloropropane-1,2-diol, numerous studies have shown that this compound(SMILES:OC[C@H](O)CCl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Spontaneous Resolution of Chiral 3-(2,3-Dimethylphenoxy)propane-1,2-diol under the Circumstances of an Unusual Diversity of Racemic Crystalline Modifications, published in 2017-08-02, which mentions a compound: 60827-45-4, Name is (2S)-(+)-3-Chloropropane-1,2-diol, Molecular C3H7ClO2, Name: (2S)-(+)-3-Chloropropane-1,2-diol.

Depending on the conditions of crystallization from solutions, racemic 3-(2,3-dimethylphenoxy)propane-1,2-diol 1 forms 3 relatively stable crystalline modifications. Each of the crystalline forms, namely, 2 polymorphic racemic compounds and a racemic conglomerate, was characterized by single-crystal x-ray diffraction. Two more metastable racemic compounds crystallized from the racemic melt were found by DSC method. Addnl. thermochem. studies allowed to plot the dependence of the free Gibbs energy on temperature for all the phases found. With the help of slurrying experiments, the nature of the transitions between solid phases was specified. Even a slight predominance of 1 of the enantiomers in almost racemic 1 samples ensures the crystallization of the conglomerate. The revealed features of rac-1 crystallization were taken into account during the realization of its resolution into individual enantiomers by the entrainment procedure.

Although many compounds look similar to this compound(60827-45-4)Name: (2S)-(+)-3-Chloropropane-1,2-diol, numerous studies have shown that this compound(SMILES:OC[C@H](O)CCl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com