Reference of 2-Methylglutaronitrile. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Methylglutaronitrile, is researched, Molecular C6H8N2, CAS is 4553-62-2, about Optimization of an immobilized-cell biocatalyst for production of 4-cyanopentanoic acid.
Optimization of microbial cell immobilization, catalyst specific activity, and volumetric productivity were required for scale-up of the nitrilase-catalyzed hydrolysis of 2-methylglutaronitrile to 4-cyanopentanoic acid, an intermediate in the preparation of 1,5-dimethyl-2-piperidone. As an alternative to the immobilization of Acidovorax facilis 72W cells in carrageenan, immobilization in alginate, followed by crosslinking with glutaraldehyde and polyethylenimine, produced a catalyst which was stable in reaction mixtures containing high concentrations of 4-cyanopentanoic acid ammonium salt. Immobilization in alginate produced catalysts with a higher nitrilase specific activity than was achieved in carrageenan, and volumetric productivity of 4-cyanopentanoic acid was increased from 19 to 49 g/L-h. Substituting alginate for carrageenan also eliminated 1 process step in the immobilization. A further increase in volumetric productivity to 79 g/L-h was achieved by using an immobilized Escherichia coli transformant which expresses A. facilis 72W nitrilase.
After consulting a lot of data, we found that this compound(4553-62-2)Reference of 2-Methylglutaronitrile can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com